【حصرياً】 mTOR_Pathway_and_mTOR_Inhibitors in_Cancer_Therapy ~_Cancer_Drug_Discovery_and_Development

الموضوع في 'كلية الصيدلة' بواسطة AHMED FIRST, بتاريخ ‏يوليو 25, 2010.

  1. AHMED FIRST

    AHMED FIRST مستشار كلية العلوم ملك الحصريات إداري

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    mTOR_Pathway_and_mTOR_Inhibitors_in Cancer_Therapy
    (Cancer_Drug_Discovery_and_Development)
    By
    Vitaly_A._Polunovsky,_Peter_J._Houghton





    • Publisher: H_um*ana_Press
    • Number Of Pages: 235
    • Publication Date: 2010-08-01
    • ASIN: 16_03_2727_04
    • EAN: 978_16032_72704

    Preface
    The main objective of this book is to provide an up-to-date survey of the rapidly advancing field of cancer therapy. Moreover, since our knowledge in this area rapidly evolves, some data have got obsolete during the process of book editing. Our understanding of the mechanisms involved in cancer genesis and progression underwent unprecedented expansion during the last decade, opening a new era of
    cancer_treatment – targeted therapy. The surge in this area results in no small part from studies conducted jointly by basic health scientists and clinical investigators. It is our hope that this book will help foster even further collaboration between investigators in these two disciplines.
    The target of rapamycin (TOR) was first identified in Saccharomyces cerevisiae and subsequently in mammals (mTOR) as a conserved atypical serine/threonine kinase. In mammalian cells, mTOR exists in at least two multi-protein complexes that have critical roles in regulating cellular homeostasis and survival. As with many other areas of science, discovery of TOR signaling was fortuitous. Rapamycin was isolated as a product of the soil bacteria Streptomyces hygroscopicus, identified in a soil sample taken from the island of Rapa Nui (Easter Island). Rapamycin was first discovered to be a potent antifungal agent and next as an immune suppressive drug. It was only later that it was found to be active as an antitumor agent in non-clinical models; although it was not developed for this indication.
    Contents
    mTORC1: A Signaling Integration Node Involved in Cell Growth . ......................... 1 a
    Neil_Kubica and John_Blenis
    The Regulation of the IGF-1/mTOR Pathway by the p53 Tumor
    Suppressor Gene Functions . . . . . . . . . . . . . . . . . . . . . ................................. . . . 37 a
    Zhaohui_Feng and Arnold_J. Levine
    mTOR Signaling in Angiogenesis . . . . . . . . . . . . . . . . . . . ................................. . . 49 a
    Henry_Mead, Mirjana_Zeremski, and Markus_Guba
    m*TORC1 Signaling and Hypoxia . . . . . . . . . . . . . . . . .................................. . . . . . 75 a
    James_Brugarolas
    mTOR Signaling in Glioblastoma: Lessons Learned from Bench
    to Bedside . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ........................................ . . . . 99 a
    David_Akhavan and Paul_S._Mischel
    mTOR and Cancer Therapy: General Principles . . . . . . ............................ . . . . . . 113 a
    Peter_J._Houghton
    mTOR_and Cancer_Therapy: Clinical_Development_and_Novel
    Prospects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ........................................ . . . . 133 a
    Sandrine_Faivre, Thomas_Decaens, and Eric_Raymond
    Drug_Combinations as a Therapeutic_Approach for_mTORC1
    Inhibitors_in_Human_Cancer . . . . . . . . . . . . . . . . . ................................... . . . . . . 149 a
    Madlaina_Breuleux and Heidi_A._Lane
    Downstream Targets of mTORC1 . . . . . . . . . . . . . ................................. . . . . . . . 179 a
    Bruno_D. Fonseca_and Christopher_G._Proud
    Downstream of_mTOR: Translational_Control of_Cancer . . ......................... . . . . . 201 a
    Ryan_J.O. Dowling and Nahum_Sonenberg
    Genome-Wide Analysis of Translational_Control . . . . . . . ........................... . . . . . 217 a
    Ola_Larsson_and Peter_B._Bitterman
    Translational Control of Cancer: Implications for Targeted Therapy . ................... 237 a
    Peter_B._Bitterman and Vitaly_A._Polunovsky
    Downstream from_mTOR: Therapeutic_Approaches
    to Targeting the eIF4F Translation Initiation Complex . . . . . . ........................ . . . 257 a
    Jerry_Pelletier and_Jeremy_R._Graff


    Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ............................................ . . . . . . 287
    a


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  2. marma10

    marma10 New Member

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