المصدر: 【حصرياً】 mTOR_Pathway_and_mTOR_Inhibitors in_Cancer_Therapy ~_Cancer_Drug_Discovery_and_Development في منتدى : كلية الصيدلة mTOR_Pathway_and_mTOR_Inhibitors_in Cancer_Therapy (Cancer_Drug_Discovery_and_Development) By Vitaly_A._Polunovsky,_Peter_J._Houghton Publisher: H_um*ana_Press Number Of Pages: 235 Publication Date: 2010-08-01 ASIN: 16_03_2727_04 EAN: 978_16032_72704 Preface The main objective of this book is to provide an up-to-date survey of the rapidly advancing field of cancer therapy. Moreover, since our knowledge in this area rapidly evolves, some data have got obsolete during the process of book editing. Our understanding of the mechanisms involved in cancer genesis and progression underwent unprecedented expansion during the last decade, opening a new era of cancer_treatment – targeted therapy. The surge in this area results in no small part from studies conducted jointly by basic health scientists and clinical investigators. It is our hope that this book will help foster even further collaboration between investigators in these two disciplines. The target of rapamycin (TOR) was first identified in Saccharomyces cerevisiae and subsequently in mammals (mTOR) as a conserved atypical serine/threonine kinase. In mammalian cells, mTOR exists in at least two multi-protein complexes that have critical roles in regulating cellular homeostasis and survival. As with many other areas of science, discovery of TOR signaling was fortuitous. Rapamycin was isolated as a product of the soil bacteria Streptomyces hygroscopicus, identified in a soil sample taken from the island of Rapa Nui (Easter Island). Rapamycin was first discovered to be a potent antifungal agent and next as an immune suppressive drug. It was only later that it was found to be active as an antitumor agent in non-clinical models; although it was not developed for this indication.Contents mTORC1: A Signaling Integration Node Involved in Cell Growth . ......................... 1 a Neil_Kubica and John_Blenis The Regulation of the IGF-1/mTOR Pathway by the p53 Tumor Suppressor Gene Functions . . . . . . . . . . . . . . . . . . . . . ................................. . . . 37 a Zhaohui_Feng and Arnold_J. Levine mTOR Signaling in Angiogenesis . . . . . . . . . . . . . . . . . . . ................................. . . 49 a Henry_Mead, Mirjana_Zeremski, and Markus_Guba m*TORC1 Signaling and Hypoxia . . . . . . . . . . . . . . . . .................................. . . . . . 75 a James_Brugarolas mTOR Signaling in Glioblastoma: Lessons Learned from Bench to Bedside . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ........................................ . . . . 99 a David_Akhavan and Paul_S._Mischel mTOR and Cancer Therapy: General Principles . . . . . . ............................ . . . . . . 113 a Peter_J._Houghton mTOR_and Cancer_Therapy: Clinical_Development_and_Novel Prospects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ........................................ . . . . 133 a Sandrine_Faivre, Thomas_Decaens, and Eric_Raymond Drug_Combinations as a Therapeutic_Approach for_mTORC1 Inhibitors_in_Human_Cancer . . . . . . . . . . . . . . . . . ................................... . . . . . . 149 a Madlaina_Breuleux and Heidi_A._Lane Downstream Targets of mTORC1 . . . . . . . . . . . . . ................................. . . . . . . . 179 a Bruno_D. Fonseca_and Christopher_G._Proud Downstream of_mTOR: Translational_Control of_Cancer . . ......................... . . . . . 201 a Ryan_J.O. Dowling and Nahum_Sonenberg Genome-Wide Analysis of Translational_Control . . . . . . . ........................... . . . . . 217 a Ola_Larsson_and Peter_B._Bitterman Translational Control of Cancer: Implications for Targeted Therapy . ................... 237 a Peter_B._Bitterman and Vitaly_A._Polunovsky Downstream from_mTOR: Therapeutic_Approaches to Targeting the eIF4F Translation Initiation Complex . . . . . . ........................ . . . 257 a Jerry_Pelletier and_Jeremy_R._Graff Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ............................................ . . . . . . 287 a Link password ahmed4friends (inlove) :gift: