Integrated Drug Discovery Technologies
Contents
Introduction
The Motivation: A Top-Down View
Part I: From Gene to Screen
Target Identification and Validation: Coupling Genotype to Phenotype
Functional Genomics
Integrated Proteomics Technologies
Where Science Meets Silicon: Microfabrication Techniques and Their Scientific Applications
SNP Scoring for Drug Discovery Applications
Protein Display Chips
Integrated Proteomics Technologies and In Vivo Validation of Molecular Targets
Part II: High-Throughput Screening
High-Throughput Screening as a Discovery Resource
Fluorescence Correlation Spectroscopy (FCS) and FCS-Related Confocal Fluorimetric Methods (FCS+ plus): Multiple Read-Out Options for Miniaturized Screening
Homogeneous Time-Resolved Fluorescence
ADME-Tox Screening in Drug Discovery
Screening Lead Compounds in the Postgenomic Era: An Integrated Approach to Knowledge Building from Living Cells
Miniaturization Technologies for High-Throughput Biology
Data Management for High-Throughput Screening
Part III: High-Throughput Chemistry
Combinatorial Chemistry: The History and the Basics
New Synthetic Methodologies
Supports for Solid-Phase Synthesis
The NMR "Toolkit" for Compound Characterization
Materials Management
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