Properties of piezoresistive silicon nano-scale cantilevers with applications to BioNEMS
2006
2006
Introduction
Techniques from nanoscience now enable the creation of ultra small electronic devices. Among these, nano electromechanical systems (NEMS) in particular offer unprecedented opportunities for sensitive chemical, biological, and physical measurements. For vacuum-based applications NEMS provide extremely high force and mass sensitivity, ultimately below the attonewton and single-Dalton level respectively. In fluidic media, even though the high quality factors attainable in vacuum become precipitously damped due to fluid coupling, extremely small device size and high compliance still yield force
sensitivity at the pico newton level – i.e., smaller than that, on average, required to break individual hydrogen bonds that are the fundamental structural elements underlying molecular recognition processes. A profound and unique new feature of nanoscale fluid based mechanical sensors is that they offer the advantage of unprecedented signal bandwidth (>>1MHz), even at pico newton force levels. Their combined sensitivity and temporal resolution is destined to enable real-time observations of stochastic single molecular biochemical processes down to the sub-microsecond regime
Link: 5.80 MB
http://thesis.library.caltech.edu/1060/1/Jessica-Arlett-thesis-finalversion-Mar2206.pdf
GOO(doh) Luck
Techniques from nanoscience now enable the creation of ultra small electronic devices. Among these, nano electromechanical systems (NEMS) in particular offer unprecedented opportunities for sensitive chemical, biological, and physical measurements. For vacuum-based applications NEMS provide extremely high force and mass sensitivity, ultimately below the attonewton and single-Dalton level respectively. In fluidic media, even though the high quality factors attainable in vacuum become precipitously damped due to fluid coupling, extremely small device size and high compliance still yield force
sensitivity at the pico newton level – i.e., smaller than that, on average, required to break individual hydrogen bonds that are the fundamental structural elements underlying molecular recognition processes. A profound and unique new feature of nanoscale fluid based mechanical sensors is that they offer the advantage of unprecedented signal bandwidth (>>1MHz), even at pico newton force levels. Their combined sensitivity and temporal resolution is destined to enable real-time observations of stochastic single molecular biochemical processes down to the sub-microsecond regime
Link: 5.80 MB
http://thesis.library.caltech.edu/1060/1/Jessica-Arlett-thesis-finalversion-Mar2206.pdf
GOO(doh) Luck
