Book Description
The latest edition of this highly acclaimed textbook, provides a comprehensive and up-to-date overview of the science and medical applications of biopharmaceutical products. Biopharmaceuticals refers to pharmaceutical substances derived from biological sources, and increasingly, it is synonymous with ‘newer’ pharmaceutical substances derived from genetic engineering or hybridoma technology.
This superbly written review of the important areas of investigation in the field, covers drug production, plus the biochemical and molecular mechanisms of action together with the biotechnology of major biopharmaceutical types on the market or currently under development. There is also additional material reflecting both the technical advances in the area and detailed information on key topics such as the influence of genomics on drug discovery.
Table of Contents
Preface
Ch. 1 Pharmaceuticals, biologics and biopharmaceuticals 1
Ch. 2 The drug development process 43
Ch. 3 The drug manufacturing process 93
Ch. 4 The cyotkines - the interferon family 189
Ch. 5 Cytokines: interleukins and tumour necrosis factor 223
Ch. 6 Haemopoietic growth factors 255
Ch. 7 Growth factors 277
Ch. 8 Hormones of therapeutic interest 303
Ch. 9 Blood products and therapeutic enzymes 351
Ch. 10 Antibodies, vaccines and adjuvants 403
Ch. 11 Nucleic acid therapeutics 463
App. 1 Biopharmaceuticals thus far approved in the USA or European Union 499
App. 2 Some Internet addresses relevant to the biopharmaceutical sector 509
App. 3 Two selected monographs reproduced from the European Pharmacopoeia (Products of recombinant DNA technology; Interferon a-2 concentrated solution) 515
App. 4 Manufacture of biological medicinal products for human use 527
Index 533
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