بسم الله الرحمن الرحيم
السلام عليكم ورحمة الله وبركاته
اخوتى واخواتى
اهدى لكم اليوم كتاب جميل بعنوان
Current Perspectives in microRNAs
Editor : Shao-Yao Ying
No.of pages: 461
Abstract
MicroRNAs are single-stranded regulatory RNAs of 18–25 nucleotide
length generated from endogenous transcripts that form local hairpin structures.
The processing of microRNA transcripts involves the activities of two RNase III
enzymes Drosha and Dicer. In this study we analyzed structural features of human
microRNA precursors that make these transcripts Drosha and Dicer substrates.
The structures of minimal functional primary precursors (pri-microRNAs) and
secondary precursors (pre-microRNAs) were predicted. The frequency, nucleotide
sequence content and the localization of various structure destabilizing motifs was
analyzed. We identified numerous pri-microRNAs which structures strongly depart
from the consensus structure and their processing is hard to explain by the existing
model of the Microprocessor complex. We also found a biased distribution of symmetric
and asymmetric motifs along the pre-microRNA hairpin stem and an over representation
of bulges on its 5′ arm (p < 0.000001), which may have considerable
functional implications.
DOWNLOAD with a direct link
http://download448.mediafire.com/ntgjo1i3j1zg/rndnzzwccmn/Current+Perspectives+in+microRNAs.pdf
لا تنسونى من صالح دعائكم
اخوكم محمد
السلام عليكم ورحمة الله وبركاته
اخوتى واخواتى
اهدى لكم اليوم كتاب جميل بعنوان
Current Perspectives in microRNAs
Editor : Shao-Yao Ying
No.of pages: 461
Abstract
MicroRNAs are single-stranded regulatory RNAs of 18–25 nucleotide
length generated from endogenous transcripts that form local hairpin structures.
The processing of microRNA transcripts involves the activities of two RNase III
enzymes Drosha and Dicer. In this study we analyzed structural features of human
microRNA precursors that make these transcripts Drosha and Dicer substrates.
The structures of minimal functional primary precursors (pri-microRNAs) and
secondary precursors (pre-microRNAs) were predicted. The frequency, nucleotide
sequence content and the localization of various structure destabilizing motifs was
analyzed. We identified numerous pri-microRNAs which structures strongly depart
from the consensus structure and their processing is hard to explain by the existing
model of the Microprocessor complex. We also found a biased distribution of symmetric
and asymmetric motifs along the pre-microRNA hairpin stem and an over representation
of bulges on its 5′ arm (p < 0.000001), which may have considerable
functional implications.
DOWNLOAD with a direct link
http://download448.mediafire.com/ntgjo1i3j1zg/rndnzzwccmn/Current+Perspectives+in+microRNAs.pdf
لا تنسونى من صالح دعائكم
اخوكم محمد