Analytical and Practical Aspects of Drug Testing in Hair

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    Analytical and Practical Aspects of
    Drug Testing in Hair
    (Forensic Science)
    By Pascal Kintz

    [​IMG]


    Publisher: CRC
    • Number Of Pages: 382
    • Publication Date: 2006-08-30
    • ISBN-10 / ASIN: 0849364507
    • ISBN-13 / EAN: 9780849364501
    • Binding: Hardcover
    Product Description


    Many advances have been made since the publication of Drug Testing in Hair. The mid-1990s witnessed the progress in cannabis detection while the late 1990s focused on benzodiazepines detection and the applications in doping control. In more recent years, toxicologists centered on the detection in hair of a single exposure and the related applications in drug-facilitated crimes. Presenting these topics as well as the latest findings from the international community, Analytical and Practical Aspects of Drug Testing in Hair reviews all new developments, the validation of analytical procedures, and the interpretation of data. Written by well-known, international authors, this comprehensive reference provides practical coverage of the best drug testing techniques and examines the drugs themselves. Some of the applications discussed include doping, drug-facilitated crime investigating, workplace testing, and the granting of drivers' licenses. The authors describe specific drugs, such as opiates, cocaine, and cannabis, and discuss the different testing methods for them. The book also covers postmortem toxicology, pitfalls created by passive exposure, and testing for metals, including inductively coupled plasma spectrometry (ICP-MS), hair multielementary analysis, and the new speciation analysis. A complete, up-to-date resource that explains numerous drug testing techniques, Analytical and Practical Aspects of Drug Testing in Hair provides useful information for toxicologists, forensic scientists, sports medicine specialists, and pathologists.



    Contents

    Drug Incorporation into Hair


    • Hair Physiology
    Drug Incorporation Routes


    Mechanisms of Binding
    Passive Exposure, Decontamination Procedures, Cutoffs, and Bias


    • Historical Concerns for Passive Exposure in Hair Analysis
    Mechanisms for Incorporation of Drugs into Hair
    Drugs in the Environment
    Decontamination Procedures
    Cutoffs and Why They Matter
    Bias in Hair Testing
    Opioids Testing in Hair


    • Opiates
    Hair Analysis for Cocaine


    • Analytical Methodologies
    Quality Control
    Interpretation of Results
    Determination of Cannabinoids in Human Hair


    • Metabolism, Incorporation of Cannabinoids into Hair
    Analytical Techniques for the Detection of Cannabinoids Decontamination Processes
    Issues to Be Considered
    Criteria for Obtaining a Cannabis-Positive Hair-Test Result
    Controlled Studies: Empirical Data Analysis of a Large Sample of
    Hair Specimens
    Reported Concentrations of Cannabinoids in Hair
    Amphetamine Determination in Hair


    • Amphetamine Determination
    Pharmaceuticals in Hair

    Screening Strategies in Hair Analysis on Drugs

    • Immunochemical Screening in Hair Analysis
    Screening and Confirmation by GC-MS/MS
    Multianalyte Screening Using LC-MS/MS
    Crime Cases Solved by Screening Hair Using LC-MS/MS
    Clinical Applications of Hair Analysis


    • Hair Analysis in Psychiatric Patients
    Hair Analysis in Epileptic Management
    Hair Analysis as Evidence of Prenatal and Postnatal Exposure to
    Drugs and Tobacco
    Hair Nicotine as a Marker of Active and Passive Exposure to Tobacco
    Drug Addiction and Opiate-Maintenance Programs
    Therapeutic Drug Monitoring
    Hair in Postmortem Toxicology


    • Methodological Aspects
    Strategies in Postmortem Work
    Detection of Doping Agents in Human Hair


    • Detection of Doping Agents
    Applications of Hair in Drug-Facilitated Crime Evidence


    • Analytical Strategy
    Application of Hair in Driving-License Regranting


    • Sensitivity of Drug Abuse Detection: Comparison between
    Urine and Hair Analysis
    Hair Sampling for Drug Analysis
    Manipulation of Drug Concentrations in Hair
    Hair Analysis for Regranting Driver's License
    Regulations in Other Countries
    Alcohol Markers in Hair


    • General Problems in Detection of Chronic Alcohol Abuse
    Fatty Acid Ethyl Esters (FAEE)
    Ethylglucuronide (EtG)
    Combined Use of FAEE and EtG
    Benzoylecgonine Ethyl Ester (Cocaethylene, BE-Et)
    Workplace Drug Testing Using Hair Samples


    • Sample Collection
    Screening Procedures
    Sample Preparation: Washing and Extraction Methods
    Confirmation by Mass Spectrometry
    Testing Body Hair Samples in Workplace Testing
    Metals


    • Hair Metal Incorporation
    Hair Washing Procedure and Sample Preparation
    Hair Elements Analytical Methods
    Metal Hair Reference Values
    Hair Metal Analysis Interpretation
    Hair Metal Analysis Results
    Metal Hair Certified Reference Material
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