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[حصريا]
كتاب
Bioisosteres in Medicinal Chemistry
Nathan Brown
2012
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.
As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development
The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of
protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed
As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development
The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of
protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed
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