Caffeine is prepared from theophylline, carbon monoxide and methanol The present invention relates to a novel process for the preparation of caffeine. Caffeine is generally obtained industrially by reacting the sodium or potassium salt of theophylline with a methylating agent, preferably dimethyl sulfate or methyl chloride (Kirk-Othmer, Encyclopedia of Chemical Technology, 2nd edition, Volume 3, page 916). However, dimethyl sulfate has the disadvantage that it is very toxic, and special safety measures are necessary when handling it. It is true that this disadvantage is substantially overcome by using methyl chloride, but in both cases a relatively large molar excess of the methylating agent must be used to achieve a high caffeine yield. This means that a high proportion of the methyl chloride or dimethyl sulfate is lost from the caffeine synthesis by non-methylating hydrolysis to methanol. Moreover, the methyl chloride and dimethyl sulfate have to be produced in a separate stage from methanol and hydrogen chloride or, respectively, sulfuric acid. It is an object of the present invention to provide a simpler process for the preparation of caffeine. We have found that this object is achieved by a process for the preparation of caffeine wherein methanol and carbon monoxide are reacted with an alkali metal salt of theophylline. The reaction can be represented by the following equation: ##STR1## where M is an alkali metal atom. Sodium formate, which is produced industrially from sodium hydroxide solution and carbon monoxide, is obtained in this caffeine synthesis and constitutes a further useful product. Preferably, in the novel synthesis of caffeine, the sodium or potassium salt of theophylline is heated to 120.degree.-170.degree. C., preferably 130.degree.-150.degree. C., with carbon monoxide and an excess of methanol. The carbon monoxide pressure in the reaction vessel is advantageously 25-100 bar, preferably 40-60 bar. In the reaction, according to the invention, of theophylline with methanol and carbon monoxide, some of the methanol used in excess reacts with the carbon monoxide, but the methyl formate thereby formed does not present any problems in the process, because methyl formate can also be used instead of the mixture of methanol and carbon monoxide for the methylation of theophylline. If methyl formate is used, it is possible to dispense with the addition of carbon monoxide entirely. The noval process substantially simplifies the preparation of caffeine, and moreover gives a good yield of highly pure product. The Examples which follow illustrate the invention further. EXAMPLE 1 A mixture of 100 g of methanol and 22.6 g of the potassium salt of theophylline is heated at 140.degree. C. in a 200 ml stirred autoclave under a continual CO pressure of 50 bar for 20 hours. The contents of the reactor are flushed into a distillation flask with methanol, and the methanol and methyl formate are distilled off. 29.5 g of a mixture of caffeine and potassium formate which, according to thin layer chromatography, contains only 0.6% of theophylline are obtained as a solid distillation residue. 19.2 g (97%) of caffeine can be extracted from the residue with ethyl acetate. EXAMPLE 2 A mixture of 50 g of methanol, 50 g of methyl formate and 22.0 g of the potassium salt of theophylline is heated at 140.degree. C. in a stirred autoclave for 20 hours. The mixture is worked up as described in Example 1 to give 29.7 g of a distillation residue composed of 18.7 g of caffeine, 0.18 g of theophylline and 10 g of potassium formate. The caffeine yield is 97.5%.
اخي العزيز وليد اعلم ان هنالك مثلا يقول اذا كان صاحبك عسل لا تلحسو كلو ولكن والله املي فيك كبيرا بعد الله سبحانه وتعالي وليد اعلمك ان بعضا من التفاعلات تعزر رؤيتها لضغر حجم الخط والبعض الاخر تعذر فهمه فهل اغالي ان طلبت منك تلخيصا للتفاعلات على الورد ويكون قابلا للتعديل والتغير اتنمنى ان تقف الي جواري هذه اليومين فأنا والله في ضيقه ما يعلم بيها الا ربنا
البحث دا أكيد هيساعد ان شاء الله مع بقية الأبحاث ما عليكى ان انتى تنظمى نفسك الكافيين يعتبر مشتق من البيورين البيورين دى اسم العيلة الكافيين والثيوبرومين والثيوفيللين هما مشتقات للبيورين الأم الكافيين يا اما يتحضر من الثيوبرومين أو الثيوفيللين شوفى البحث دا فى تحضير الثيوفيللين
Synthesis of Purines وكمان برده تشمل تحضير الكافيين أو الثيوبرومين أو الثيوفيللين كمشتقات البيورينز The Purines have been synthesized by two main synthetic routes appropriately substituted using either Pyrimidine OR Imidazole Derivatives, each with many variation anf refinements
دى paper فى تحضير Alkylation of the cyclic homolog of xanthine in the methyl iodide-sodium hydride system as a function of the reagent-alkylating system ratio yields different products: for a 1:3 ratio of reagents, a homolog of caffeine is formed, while for a 1:2 ratio, a homolog of theobromine is formed. In contrast to xanthine, methylation of its cyclic homolog initially takes place at the imidazole ring and occurs in the sequence N(t ), N(4 ), N(7
ادخل الموقع التالى عسى ينفعك وفيه كتب كيمياء تم حذف موقع إسرائيلي و محذور عندنا في الإمارات و وجب التنبيه لمثل هذه المواقع
ادخل الموقع التالى عسى ينفعك وفيه كتب كيمياء ############# لا يجوز وضع روابط لمنتديات أخرى فهذا يعتبر دعاية صرحة ###################################
شكرا وليد وتسلم يا محمد بس عزيزي وليد انا طلبت منك التفاعلات خقت الكافين اللي انت اعطيتني هي نفسها بس لو ممكن تحطلي هي على ملف ورد عادي وتسلم تعبتك وليد بكره البرزتتاشن ارجوك ان تستنفر قواك معاي و الف شكر ياغالي
عزيزي وليد في في واحد من التفاعلات اللي انت اضفتلي هي شئ اسموا Modern carbon وبيضعوا فوقها * ايش يعني
معلش واللهى يا رانو لسة راجع البيت بعد سفر طويل اليوم modern carbonاللى عليها * تعنى ان دى كربون-14 أى يتم ادخال كربون-14 اى حدث ترقيم
ثانيا التفاعلات دى موجودة فى البحث والموضوع بيتكلم عن Identification of Caffeine as Natural or Synthetic أى التفرقة بين الكافيين المستخلص طبيعياً من أوراق الشاى والقهوة والكافيين المحضر معملياً عن طريق استخدام تقنية الترقيم بالكربون - 14
اها فهمت بارك الله فيك طيب ممكن تسميلي كل المركبات الموجوده في التفاعل هدا الله يسعدك كمان ممكن تقلي بأيت تفاعل ممكن ادخل methyl group على اليوريا الحمد له على سلامتك والله سامحني تعبتك بس والله مانمت من امس الساعه اربعة ولسه ما خلصت التحضيرات الله يبارك فيك كمان ابغى اعرف اذا تعرف ايش يعني lypolitic and thermogenic
